Effects of Dexmedetomidine on Oxidative Stress, Inflammatory Response, Coagulation Function and Hemodynamics in Patients Undergoing Hysterectomy

Liao Ou; Zhang Xian-jie; Chen Juan

doi:doi:10.11648/j.ijacm.20241201.16

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Effects of Dexmedetomidine on Oxidative Stress, Inflammatory Response, Coagulation Function and Hemodynamics in Patients Undergoing Hysterectomy

Liao Ou

, Zhang Xian-jie^*

, Chen Juan

Published in International Journal of Anesthesia and Clinical Medicine (Volume 12, Issue 1)

Received: 11 March 2024 Accepted: 2 April 2024 Published: 28 April 2024

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Abstract

Objective To investigate the effects of dexmedetomidine on oxidative stress, inflammatory response, coagulation function and hemodynamics in patients undergoing hysterectomy. Methods 92 patients who underwent hysterectomy in our hospital from January to September 2023 were selected as subjects. According to the difference in anesthesia, 46 patients were in the control group and 46 in the dexmedetomidine group. Patients in the control group received midazolam anesthesia, and patients in the dexmedetomidine group received dexmedetomidine anesthesia. The changes of oxidative stress, inflammatory response, coagulation function and hemodynamics were compared between T0 (before anesthesia), T1 (10 min after anesthesia), T2 (after extubation) and T3 (24 h after surgery). Results At T0, there was no significant difference in T-AOC, GSH-Px, MBP, MCP-1, AT III, FDP, MAP and SpO₂ between the two groups (P>0.05). At the time of T1, T2 and T3, the two groups of patients T-AOC, GSH-Px were all lower than T0 (P<0.05), MBP and MCP-1 were all higher than T0 (P<0.05). The levels of T-AOC and GSH-Px in the dexmedetomidine group were significantly higher than those in the control group (P<0.05). The levels of MCP-1 was significantly lower than that of the control group (P<0.05). At the T1 and T2, ATIII levels was lower than T0 (P<0.05), and FDP levels was higher than T0 (P<0.05). At the time of T3, the levels of ATIII and FDP in the dexmedetomidine group recovered to the normal level of T0. There was no significant change in MAP and SpO₂ at each time in the dexmedetomidine group (P>0.05). Conclusion Dexmedetomidine can more effectively alleviate the oxidative stress response in patients with hysterectomy, reduce the symptoms of inflammation in patients, improve the coagulation status of patients and have less influence on hemodynamics, and have high clinical value.

Published in	International Journal of Anesthesia and Clinical Medicine (Volume 12, Issue 1)
DOI	10.11648/j.ijacm.20241201.16
Page(s)	26-32
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Dexmedetomidine, Total Hysterectomy, Oxidative Stress, Inflammatory Response, Coagulation, Hemodynamics

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APA Style

Ou, L., Xian-jie, Z., Juan, C. (2024). Effects of Dexmedetomidine on Oxidative Stress, Inflammatory Response, Coagulation Function and Hemodynamics in Patients Undergoing Hysterectomy. International Journal of Anesthesia and Clinical Medicine, 12(1), 26-32. https://doi.org/10.11648/j.ijacm.20241201.16

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ACS Style

Ou, L.; Xian-jie, Z.; Juan, C. Effects of Dexmedetomidine on Oxidative Stress, Inflammatory Response, Coagulation Function and Hemodynamics in Patients Undergoing Hysterectomy. Int. J. Anesth. Clin. Med. 2024, 12(1), 26-32. doi: 10.11648/j.ijacm.20241201.16

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AMA Style

Ou L, Xian-jie Z, Juan C. Effects of Dexmedetomidine on Oxidative Stress, Inflammatory Response, Coagulation Function and Hemodynamics in Patients Undergoing Hysterectomy. Int J Anesth Clin Med. 2024;12(1):26-32. doi: 10.11648/j.ijacm.20241201.16

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@article{10.11648/j.ijacm.20241201.16,
  author = {Liao Ou and Zhang Xian-jie and Chen Juan},
  title = {Effects of Dexmedetomidine on Oxidative Stress, Inflammatory Response, Coagulation Function and Hemodynamics in Patients Undergoing Hysterectomy
},
  journal = {International Journal of Anesthesia and Clinical Medicine},
  volume = {12},
  number = {1},
  pages = {26-32},
  doi = {10.11648/j.ijacm.20241201.16},
  url = {https://doi.org/10.11648/j.ijacm.20241201.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijacm.20241201.16},
  abstract = {Objective To investigate the effects of dexmedetomidine on oxidative stress, inflammatory response, coagulation function and hemodynamics in patients undergoing hysterectomy. Methods 92 patients who underwent hysterectomy in our hospital from January to September 2023 were selected as subjects. According to the difference in anesthesia, 46 patients were in the control group and 46 in the dexmedetomidine group. Patients in the control group received midazolam anesthesia, and patients in the dexmedetomidine group received dexmedetomidine anesthesia. The changes of oxidative stress, inflammatory response, coagulation function and hemodynamics were compared between T0 (before anesthesia), T1 (10 min after anesthesia), T2 (after extubation) and T3 (24 h after surgery). Results At T0, there was no significant difference in T-AOC, GSH-Px, MBP, MCP-1, AT III, FDP, MAP and SpO2 between the two groups (P>0.05). At the time of T1, T2 and T3, the two groups of patients T-AOC, GSH-Px were all lower than T0 (PPPPPP2 at each time in the dexmedetomidine group (P>0.05). Conclusion Dexmedetomidine can more effectively alleviate the oxidative stress response in patients with hysterectomy, reduce the symptoms of inflammation in patients, improve the coagulation status of patients and have less influence on hemodynamics, and have high clinical value.
},
 year = {2024}
}

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TY  - JOUR
T1  - Effects of Dexmedetomidine on Oxidative Stress, Inflammatory Response, Coagulation Function and Hemodynamics in Patients Undergoing Hysterectomy

AU  - Liao Ou
AU  - Zhang Xian-jie
AU  - Chen Juan
Y1  - 2024/04/28
PY  - 2024
N1  - https://doi.org/10.11648/j.ijacm.20241201.16
DO  - 10.11648/j.ijacm.20241201.16
T2  - International Journal of Anesthesia and Clinical Medicine
JF  - International Journal of Anesthesia and Clinical Medicine
JO  - International Journal of Anesthesia and Clinical Medicine
SP  - 26
EP  - 32
PB  - Science Publishing Group
SN  - 2997-2698
UR  - https://doi.org/10.11648/j.ijacm.20241201.16
AB  - Objective To investigate the effects of dexmedetomidine on oxidative stress, inflammatory response, coagulation function and hemodynamics in patients undergoing hysterectomy. Methods 92 patients who underwent hysterectomy in our hospital from January to September 2023 were selected as subjects. According to the difference in anesthesia, 46 patients were in the control group and 46 in the dexmedetomidine group. Patients in the control group received midazolam anesthesia, and patients in the dexmedetomidine group received dexmedetomidine anesthesia. The changes of oxidative stress, inflammatory response, coagulation function and hemodynamics were compared between T0 (before anesthesia), T1 (10 min after anesthesia), T2 (after extubation) and T3 (24 h after surgery). Results At T0, there was no significant difference in T-AOC, GSH-Px, MBP, MCP-1, AT III, FDP, MAP and SpO2 between the two groups (P>0.05). At the time of T1, T2 and T3, the two groups of patients T-AOC, GSH-Px were all lower than T0 (PPPPPP2 at each time in the dexmedetomidine group (P>0.05). Conclusion Dexmedetomidine can more effectively alleviate the oxidative stress response in patients with hysterectomy, reduce the symptoms of inflammation in patients, improve the coagulation status of patients and have less influence on hemodynamics, and have high clinical value.

VL  - 12
IS  - 1
ER  -

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Author Information

Liao Ou

Department of Anesthesia, Deyang People's Hospital, Deyang, China

http://orcid.org/0009-0006-9243-5299
Zhang Xian-jie

Department of Anesthesia, Deyang People's Hospital, Deyang, China

Contact Email

http://orcid.org/0009-0001-8637-5676
Chen Juan

Second Internal Department, Deyang Integrated Traditional Chinese and Western Medicine Hospital, Deyang, China

http://orcid.org/0009-0005-0505-2680

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APA Style

Ou, L., Xian-jie, Z., Juan, C. (2024). Effects of Dexmedetomidine on Oxidative Stress, Inflammatory Response, Coagulation Function and Hemodynamics in Patients Undergoing Hysterectomy. International Journal of Anesthesia and Clinical Medicine, 12(1), 26-32. https://doi.org/10.11648/j.ijacm.20241201.16

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ACS Style

Ou, L.; Xian-jie, Z.; Juan, C. Effects of Dexmedetomidine on Oxidative Stress, Inflammatory Response, Coagulation Function and Hemodynamics in Patients Undergoing Hysterectomy. Int. J. Anesth. Clin. Med. 2024, 12(1), 26-32. doi: 10.11648/j.ijacm.20241201.16

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AMA Style

Ou L, Xian-jie Z, Juan C. Effects of Dexmedetomidine on Oxidative Stress, Inflammatory Response, Coagulation Function and Hemodynamics in Patients Undergoing Hysterectomy. Int J Anesth Clin Med. 2024;12(1):26-32. doi: 10.11648/j.ijacm.20241201.16

Copy | Download

@article{10.11648/j.ijacm.20241201.16,
  author = {Liao Ou and Zhang Xian-jie and Chen Juan},
  title = {Effects of Dexmedetomidine on Oxidative Stress, Inflammatory Response, Coagulation Function and Hemodynamics in Patients Undergoing Hysterectomy
},
  journal = {International Journal of Anesthesia and Clinical Medicine},
  volume = {12},
  number = {1},
  pages = {26-32},
  doi = {10.11648/j.ijacm.20241201.16},
  url = {https://doi.org/10.11648/j.ijacm.20241201.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijacm.20241201.16},
  abstract = {Objective To investigate the effects of dexmedetomidine on oxidative stress, inflammatory response, coagulation function and hemodynamics in patients undergoing hysterectomy. Methods 92 patients who underwent hysterectomy in our hospital from January to September 2023 were selected as subjects. According to the difference in anesthesia, 46 patients were in the control group and 46 in the dexmedetomidine group. Patients in the control group received midazolam anesthesia, and patients in the dexmedetomidine group received dexmedetomidine anesthesia. The changes of oxidative stress, inflammatory response, coagulation function and hemodynamics were compared between T0 (before anesthesia), T1 (10 min after anesthesia), T2 (after extubation) and T3 (24 h after surgery). Results At T0, there was no significant difference in T-AOC, GSH-Px, MBP, MCP-1, AT III, FDP, MAP and SpO2 between the two groups (P>0.05). At the time of T1, T2 and T3, the two groups of patients T-AOC, GSH-Px were all lower than T0 (PPPPPP2 at each time in the dexmedetomidine group (P>0.05). Conclusion Dexmedetomidine can more effectively alleviate the oxidative stress response in patients with hysterectomy, reduce the symptoms of inflammation in patients, improve the coagulation status of patients and have less influence on hemodynamics, and have high clinical value.
},
 year = {2024}
}

Copy | Download

TY  - JOUR
T1  - Effects of Dexmedetomidine on Oxidative Stress, Inflammatory Response, Coagulation Function and Hemodynamics in Patients Undergoing Hysterectomy

AU  - Liao Ou
AU  - Zhang Xian-jie
AU  - Chen Juan
Y1  - 2024/04/28
PY  - 2024
N1  - https://doi.org/10.11648/j.ijacm.20241201.16
DO  - 10.11648/j.ijacm.20241201.16
T2  - International Journal of Anesthesia and Clinical Medicine
JF  - International Journal of Anesthesia and Clinical Medicine
JO  - International Journal of Anesthesia and Clinical Medicine
SP  - 26
EP  - 32
PB  - Science Publishing Group
SN  - 2997-2698
UR  - https://doi.org/10.11648/j.ijacm.20241201.16
AB  - Objective To investigate the effects of dexmedetomidine on oxidative stress, inflammatory response, coagulation function and hemodynamics in patients undergoing hysterectomy. Methods 92 patients who underwent hysterectomy in our hospital from January to September 2023 were selected as subjects. According to the difference in anesthesia, 46 patients were in the control group and 46 in the dexmedetomidine group. Patients in the control group received midazolam anesthesia, and patients in the dexmedetomidine group received dexmedetomidine anesthesia. The changes of oxidative stress, inflammatory response, coagulation function and hemodynamics were compared between T0 (before anesthesia), T1 (10 min after anesthesia), T2 (after extubation) and T3 (24 h after surgery). Results At T0, there was no significant difference in T-AOC, GSH-Px, MBP, MCP-1, AT III, FDP, MAP and SpO2 between the two groups (P>0.05). At the time of T1, T2 and T3, the two groups of patients T-AOC, GSH-Px were all lower than T0 (PPPPPP2 at each time in the dexmedetomidine group (P>0.05). Conclusion Dexmedetomidine can more effectively alleviate the oxidative stress response in patients with hysterectomy, reduce the symptoms of inflammation in patients, improve the coagulation status of patients and have less influence on hemodynamics, and have high clinical value.

VL  - 12
IS  - 1
ER  -

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